Use of preventive measures, beliefs and information received about COVID-19 and their effects on mental health, in two stages of the pandemic in ColombiaObservational Study Published on 2022-12-012022-10-04 Journal: Annals of Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] age Better caused COVID-19 COVID-19 pandemic cross-sectional distress Effect GHQ-12 greater Health health system Healthcare professional IMPROVE individual information knowledge less media Mental mental health official pandemic participant performed physical Prevent preventive measure preventive measures professionals promoted Psychological distress questionnaire recommendation reducing social media. sociodemographic data Spain Stage structures was used women [DOI] 10.1080/07853890.2022.2109057 PMC 바로가기 [Article Type] Observational Study
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to OmicronArticle Published on 2022-10-062022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 100% conserved Analysis Antigen Beta caused CD4 CD4+ CD8 CD8+ T cell clade clades composed confirmed cases conserved COVID-19 cross-protective deaths Delta epitope Epitopes Epsilon Eta Gamma Genome genomes GISAID greater highly antigenic HLA binding hydrophobic IFN-γ IL-10 IL-12 IL-2 IL-6 immune response immune responses immunoinformatics in silico approaches in vivo Lambda long-lasting majority memory Metadata molecular docking Mortality Mutation non-toxic offer omicron ORF ORF1ab ORF8 proteins peptide performed promoted Protein reduced Reinfection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants secretion severity Strains suffered T cell epitope TGF-β Th1 the Spike the vaccine TLR4 Vaccine variant variants virus virus transmission WHO Wuhan [DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
Blood Endothelial-Cell Extracellular Vesicles as Potential Biomarkers for the Selection of Plasma in COVID-19 Convalescent Plasma TherapyArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] 바이오마커, [키워드] Activation age anti-SARS-CoV-2 antibody Biomarkers Blood blood endothelium cardiovascular disease caused CCP CCP therapy Characteristics characterized clinical symptom Concentration consequence convalescent plasma Convalescent plasma therapy coronavirus disease COVID-19 death Donor downregulation Endothelial cell Endothelial dysfunction Endothelium evidenced excessive inflammation expected extracellular vesicle Extracellular vesicles extracellular vesicles. hospital ICAM1 identify individual infected individual inflammatory storm massive secretion mechanism mild symptoms mitochondrial dysfunction multi-organ failure onset of symptom overexpression parameter Peripheral blood plasma Potential pro-inflammatory pro-inflammatory cytokine progression promoted reflected selected Selection severity subset Symptoms the disease therapy vaccination Vascular endothelium vascular inflammation vessel was increased [DOI] 10.3390/cells11193122 PMC 바로가기
Preparation and pre-clinical evaluation of flagellin-adjuvanted NOM vaccine candidate formulated with Spike protein against SARS-CoV-2 in mouse modelArticle Published on 2022-10-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] 3D structure acute respiratory syndrome Analysis anti-S Antigen Antisera bind Cell Cell-mediated immune responses chimeric China Cluster coronavirus cytokine develop docking effective elicit ELISA ENhance evaluated expressed flagellin groups humoral IFN-γ IgG IL-10 IL-17 IL-22 IL-6 immune response immunoinformatics indicated Infection Interaction mice Ni-NTA NOM protein ORF3a outbreak performed pneumonia case preparation promoted Protein purified raised receptor S protein Salmonella SARS-CoV-2 significantly increased spike spleen TLR5 TNF-α Total vaccination Vaccine vaccine candidate vaccine candidates vaccine. was selected were assessed Wuhan [DOI] 10.1016/j.micpath.2022.105736 PMC 바로가기
Treatment retention, return to use, and recovery support following COVID-19 relaxation of methadone take-home dosing in two rural opioid treatment programs: A mixed methods analysisResearch article Published on 2022-10-012022-10-05 Journal: Journal of substance abuse treatment [Category] 치료법, [키워드] Abuse Analysis association change clinically COVID-19 dose doses Effect EHR employment expected feasible FIVE Health increase in individual less Medication for opioid use disorder Methadone objective opioid Opioid treatment OTP Patient patients positive positive result Probability Program promoted public health Qualitative qualitative analysis Quantitative reaction reduced regimens Regression model Result rural service substance Support supported Travel Treatment triggers Urine [DOI] 10.1016/j.jsat.2022.108801 [Article Type] Research article
Biomarkers extracted by fully automated body composition analysis from chest CT correlate with SARS-CoV-2 outcome severityArticle Published on 2022-09-302022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] 95% CI adipose adjusted analysis Analysis analyzed approach association automated Biomarker body composition Chest Chest CT complex Computed tomography contribute Course death Deceased defined disease disease severity Endpoint endpoints feature female Female patients genders Infection investigated laboratory parameter male Mann-Whitney-U test marker Mortality Multiple multivariate logistic regression outcome Patient patients promoted remained risk risk stratification SARS-CoV-2 SARS-CoV-2 patients severe SARS-CoV-2 severity small patient cohort statistical significance tissue tissues two-sided Volume [DOI] 10.1038/s41598-022-20419-w PMC 바로가기
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Viral infection. Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
Trend of hand, foot, and mouth disease from 2010 to 2021 and estimation of the reduction in enterovirus 71 infection after vaccine use in Zhejiang Province, ChinaArticle Published on 2022-09-202022-11-16 Journal: PLoS ONE [Category] 치료기술, [키워드] Administered age Analysis APC average Bayesian biennial caused changes in Characteristics China COVID-19 epidemic death demographic characteristics disease distributions effective excluded expected incidence incidence rate individual Infection information measure pathogen promoted reduction in Regression model reported shown Surveillance trend vaccination Vaccine Variation virus virus was used were used Yangtze River Delta Zhejiang [DOI] 10.1371/journal.pone.0274421 PMC 바로가기
Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concernArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 canonical coronavirus coronavirus disease COVID-19 CSS Cytokine storm syndrome Genetic hemorrhages Host immune response hyperinflammation Inflammasome Inflammation less life-threatening Local long-lasting Macrophage mechanism neutrophil pandemic proinflammatory proinflammatory activity promoted Protein recruitment rescued SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant spike systemic hyperinflammation variant variants variants of concern zebrafish [DOI] 10.1126/sciadv.abo0732 PMC 바로가기
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19Article Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 치료기술, 치료제, [키워드] Activation amplified amplify analyzed blocked Blood Cell chemokine chronic liver disease Chronic Liver Diseases circulating comorbid disease Comorbidity contribute controls correlated COVID-19 COVID-19 patients Critical cytokine cytokine secretion DCLK1 DDCLK1 decrease disease severity dysregulation expression Factor Factors Gain growth factor hospitalized patient Host Hyperinflammatory response immune Immune cell immune response immunosuppressive in viral in vitro infected cells Inflammation Inflammatory cytokine inflammatory pathway inhibition inhibitor Innate immunity involved kinase Live virus liver livers loss of function lung Lung disease Macrophage mononuclear cell mononuclear cells Mortality neutrophil normalized Pathogenesis pathology Patient Peripheral blood potential therapeutic target Prevalence pro-inflammatory profile proinflammatory promoted promoter Protein S100A9 SARS-CoV-2 SARS-CoV-2-infected cell secretion severity of COVID-19 Signaling subject targeting Treatment Viremia virus production virus replication Virus replication. with COVID-19 β-catenin [DOI] 10.1128/jvi.00967-22 PMC 바로가기